{"id":13332,"date":"2024-08-01T05:34:03","date_gmt":"2024-08-01T05:34:03","guid":{"rendered":"https:\/\/new.hakimanteb.com\/?p=13332"},"modified":"2024-09-16T11:11:17","modified_gmt":"2024-09-16T07:41:17","slug":"osteoporosis-and-vitamin-k2","status":"publish","type":"post","link":"https:\/\/hakimanteb.com\/en\/osteoporosis-and-vitamin-k2\/","title":{"rendered":"Osteoporosis and vitamin K2"},"content":{"rendered":"\r\n

Osteoporosis is a systemic skeletal disorder with serious consequences that negatively affects the general health and quality of life in elderly men and women, especially postmenopausal women. Classically, calcium and vitamin D were used as supplements for prevention of osteoporosis. In recent years, the role of vitamin K2 (Menaquinone) in maintaining bone health and prevention of vascular calcification has been proven.<\/p>\r\n\r\n\r\n\r\n

Flexan CALCINORM PLUS<\/strong> tablet contains calcium, vitamins D, K2, and C, magnesium, zinc and manganese, is effective in the prevention and treatment of osteoporosis as well as maintaining cardiovascular health.<\/p>\r\n\r\n\r\n\r\n

Contains calcium, K2, D, and C vitamins, magnesium, zinc and manganese<\/strong><\/p>\r\n\r\n\r\n\r\n

\u2022The maintenance of normal bones<\/p>\r\n\r\n\r\n\r\n

\u2022 Prevention of vascular calcification due to the presence of vitamin K2<\/p>\r\n\r\n\r\n\r\n

\u2022 Prevention and treatment of osteoporosis<\/p>\r\n\r\n\r\n\r\n

\u2022 Strengthening the muscles and joints<\/p>\r\n\r\n\r\n\r\n

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Nutrition information per 1 tablet<\/strong><\/td>\r\n<\/tr>\r\n
Calcium<\/td>\r\n750 mg<\/td>\r\n<\/tr>\r\n
Magnesium<\/td>\r\n120 mg<\/td>\r\n<\/tr>\r\n
Zinc\u00a0<\/td>\r\n15 mg<\/td>\r\n<\/tr>\r\n
Manganese<\/td>\r\n2 mg<\/td>\r\n<\/tr>\r\n
Vitamin C<\/td>\r\n60 mg<\/td>\r\n<\/tr>\r\n
Vitamin D\u00a0<\/sub><\/td>\r\n25 \u00b5g (1000 IU)<\/td>\r\n<\/tr>\r\n
Vitamin K2<\/td>\r\n30 \u00b5g<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/figure>\r\n\r\n\r\n\r\n

Vitamin K2:<\/strong><\/p>\r\n\r\n\r\n\r\n

Vitamin K2 is a fat-soluble vitamin that is directly associated with higher bone mineral density (BMD) and concomitant reduction of bone turnover markers (BTMs).\u00a0<\/p>\r\n\r\n\r\n\r\n

Additionally, vitamin K2 demonstrating an increase in the elasticity and reduction in age-related arterial stiffening and could reduce progression of vascular calcification.<\/p>\r\n\r\n\r\n\r\n

Vitamin K2 deficiency increases the risk of osteoporosis and cardiovascular diseases.\u00a0<\/p>\r\n\r\n\r\n\r\n

Vitamin K2 and bone health:<\/strong><\/p>\r\n\r\n\r\n\r\n

    \r\n
  • OC (Osteocalcin) \u03b3 -carboxylation:<\/strong> Binding of Ca to bone hydroxyapatite.\u00a0<\/li>\r\n\r\n\r\n\r\n
  • Increasing osteoblastogenesis and decreasing osteoclastogenesis.<\/li>\r\n\r\n\r\n\r\n
  • The control of oxidative stress.<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n

    Vitamin K2 and heart health:\u00a0<\/strong><\/p>\r\n\r\n\r\n\r\n

      \r\n
    • MGP \u03b3-carboxylation:<\/strong> inhabitation of ectopic Ca2+ precipitation in the blood vessels.<\/li>\r\n\r\n\r\n\r\n
    • Gas6 protein: <\/strong>obstruction the arterial calcification via preventing apoptosis.\u00a0<\/li>\r\n\r\n\r\n\r\n
    • Periostin:<\/strong> Creating a protective effect against vascular calcification.\u00a0<\/li>\r\n<\/ul>\r\n\r\n\r\n\r\n
      \"\"<\/figure>\r\n\r\n\r\n\r\n

      Figure. Mechanisms of action of VitK2 in \u201cbone and vascular cross-talk\u201d (5).<\/strong><\/p>\r\n\r\n\r\n\r\n

       <\/p>\r\n\r\n\r\n\r\n