Osteoporosis is a systemic skeletal disorder with serious consequences that negatively affects the general health and quality of life in elderly men and women, especially postmenopausal women. Classically, calcium and vitamin D were used as supplements for prevention of osteoporosis. In recent years, the role of vitamin K2 (Menaquinone) in maintaining bone health and prevention of vascular calcification has been proven.

Flexan CALCINORM PLUS tablet contains calcium, vitamins D, K2, and C, magnesium, zinc and manganese, is effective in the prevention and treatment of osteoporosis as well as maintaining cardiovascular health.

Contains calcium, K2, D, and C vitamins, magnesium, zinc and manganese

•The maintenance of normal bones

• Prevention of vascular calcification due to the presence of vitamin K2

• Prevention and treatment of osteoporosis

• Strengthening the muscles and joints

Nutrition information per 1 tablet
Calcium	750 mg
Magnesium	120 mg
Zinc	15 mg
Manganese	2 mg
Vitamin C	60 mg
Vitamin D	25 µg (1000 IU)
Vitamin K2	30 µg

Vitamin K2:

Vitamin K2 is a fat-soluble vitamin that is directly associated with higher bone mineral density (BMD) and concomitant reduction of bone turnover markers (BTMs). 

Additionally, vitamin K2 demonstrating an increase in the elasticity and reduction in age-related arterial stiffening and could reduce progression of vascular calcification.

Vitamin K2 deficiency increases the risk of osteoporosis and cardiovascular diseases. 

Vitamin K2 and bone health:

• OC (Osteocalcin) γ -carboxylation: Binding of Ca to bone hydroxyapatite. 
• Increasing osteoblastogenesis and decreasing osteoclastogenesis.
• The control of oxidative stress.

Vitamin K2 and heart health: 

• MGP γ-carboxylation: inhabitation of ectopic Ca2+ precipitation in the blood vessels.
• Gas6 protein: obstruction the arterial calcification via preventing apoptosis. 
• Periostin: Creating a protective effect against vascular calcification. 

Figure. Mechanisms of action of VitK2 in “bone and vascular cross-talk” (5).